IDENTIFIKASI METABOLIT SEKUNDER DAN UJI AKTIVITAS ANTIOKSIDAN DARI EKSTRAK DAUN SAMBUNG NYAWA (Gynura procumbens (Lour.) Merr).
DOI:
https://doi.org/10.25077/jku.12.2.8-12.2023Abstract
Sambung nyawa (Gynura procumbens (Lour.) Merr) is one of the plants used in traditional medicine. This has life-saving properties such as preventing polyps, dysentery, hypertension, diabetes, and cancer. In this study, the secondary metabolite content and antioxidant activity of sambung nyawa leaf extract were tested and its antioxidant activity. The extraction process was carried out by multilevel maceration using three different solvents, starting with hexane, ethyl acetate, and methanol. Secondary metabolite content test results showed that ironwood leaves contain flavonoids, phenolics, steroids, terpenoids, and alkaloids. The result of the antioxidant activity test using the DPPH method (1,1-Difenil-2- pikrilhidrazil) showed that the methanol extract showed very strong activity with an IC50 value of 15,01 mg/L, while the ethyl acetate showed moderate antioxidant activity with an IC50 value of 147,04 mg/L, and the hexane extract showed antioxidant activity with an IC50 value of 361,66 mg/L.
References
E.M. Santoni A, Permana H, Identifikasi Senyawa Metabolit Sekunder dan Uji Antioksidan Serta Uji Toksisitas Ekstrak Daun Kayu Ara (Ficus Aurata (Miq.) Miq.), J. Kim. Unand. 5 (2016) 1–11.
Hui-Wen Lee, Antidiabetic effect of involve modulation of hepatic carbohydrate metabolism in streptozotocin-induced diabetic rats, J. Med. Plants Res. 6 (2012).
G.B. Tan HL, Chan KG, Pusparajah P, Lee LH, Gynura procumbens: An overview of the biological activities, Front Pharmacol. 7 (2016).
T.A. Shahlehi S, Azizi A, P.M. Amdani SN, Anti- hypertensive vasodilatory action of Gynura procumbens mediated by kaempferol 3-O-rutinoside, J. Biomed. Reaseach Univ. Malaya. 9 (2020).
A.R. Suriani Sinaga M, Defriska Siagian P, Pemanfaatan Ekstrak Daun Sambung Nyawa (Gynura Procumbens [Lour].Merr) Sebagai Antioksidan Pada Minyak Kelapa Menggunakan Pelarut Metanol The Utilization Of Sambung Nyawa (Gynura Procumbens [Lour].Merr) Leaves Extract As An Antioxidant For Coconut Oil By , J. Tek. Kim. USU. 6 (2017).
F.U.N. Prasetyorini, Rahmadini A, Uji Antibakteri Ekstrak Daun Sambung Nyawa (Gynura Procumbens (Lour.) Merr.) dan Daun Tapak Liman (Elephantopus Scaber L.) Terhadap Salmonella Thypi, Ekol. Ilmu Dasar Dan Lingkung Hidup. 19 (2019) 1–11.
Y. Dinni D, Bakhtra A, Jubahar J, E, Uji Aktivitas Fraksi Dari Ekstrak Daun Sambung Nyawa (Gynura Procumbens (Lour)Merr.) Terhadap Bakteri Shigella Dysenteriae, J. Farm. Higea. 10 (2018).
W.W. Oktaviani E, Harpeni E, Fitofarmaka Daun Sambung Nyawa (Gynura Procumbens) Untuk Meningkatkan Imunitas Ikan Kerapu Macan (Epinephelus Fuscoguttatus Forsskal 1775) Terhadap Serangan Bakteri Vibrio Alginolyticus, J. Kelaut. Indones. 12 (2019) 52.
R.A. Thoyibah C, Penetapan Kadar Fenol Total Dan Uji Aktivitas Antioksidan Ekstrak Daun Sambung Nyawa (Gynura procumbens (Lour.)Merr .), Publ. Online. (2019).
P. Bahriul, Uji Salam Pikrilhidrazil Antioxidant Activity Test of Bay Leave ( Syzygium polyanthum ) Extract, J Akad Kim. 3 (2014) 368–374.
I.M.O.A. Parwata, Kimia Terapan Program Pascasarjana Universitas Udayana, 2016.
B.F. Susanty S, Perbandingan Metode Ekstraksi Maserasi Dan Refluks Terhadap Kadar Fenolik Dari Ekstrak Tongkol Jagung (Zea mays L.), J. Konversi. 5 (2016) 87.
F.I. Utami YP, Farmasi BB, Tinggi S, Uji Aktivitas Antioksidan Ekstrak Etanol Akar Sambiloto (Andrographis paniculata (Burm.F.) Ness.) Dengan Metode DPPH, 4 (2021) 20–23.
F.N. Salim E, Santoni A, Penentuan Kandungan Fenolik Total, Sifat Antioksidan dan Toksisitas Dari Ekstrak Kulit Batang Rengas (Gluta renghas L.), J. Zarah. 8 (2021) 82–88.
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