Profil Fitokimia dan Uji Toksisitas Daun Tumbuhan Aglaia Odorata dengan Metode Brine Shrimp Lethality Test
DOI:
https://doi.org/10.25077/jku.11.2.1-4.2022Keywords:
Aglaia odorata, toxicity, brine shrimp lethality test , anticancer, secondary metabolitesAbstract
Toxicity and phytochemistry assay have been conducted on extracts and fractions of Aglaia odorata leaves using brine shrimp lethality test. Aglaia odorata is one of the plants that are found in Indonesia. To investigate Aglaia odorata leaves potential as anticancer, air-dried and powdered leaves were extracted with n-hexane, ethyl acetat, and metanol by using maceration method. Extract of ethyl acetat showed the highest toxicity with LC50 value is 125.89 mg/L
References
M. Efdi, D. Pratama, A. Itam, T. Okselni, Antioxidant Flavonoid Glycoside from Leaves of Cacao Mistletoe (Scurrula ferruginea (Jack) Danser), Indones. J. Chem. 22 (2022) 944–952. https://doi.org/10.22146/ijc.72133.
L.. An, F.L., Wang, J.S., Wang, H., Wang, X.B., Yang, M.H., Guo, Q.L., Dai, Y., Luo, J. and Kong, Cytotoxic Flavonol-Diamide [3+2] Adducts from the Leaves of Aglaia Odorata, Tetrahedron. 71 (2015) 2450–2457.
B. Liu, Y.K. Xu, Cytotoxicity and Synergistic Effect of the Constituents from Roots of Aglaia odorata (Meliaceae), Nat. Prod. Res. 30 (2016) 433–437. https://doi.org/10.1080/14786419.2015.1016940.
A. Dharma, D.D., Efdi, M. and Santoni, Research Article Isolation and Elucidation Structure Major Compounds from the Leaves of Aglaia Odorata Lour, 7 (2015) 121–123.
N.T.N. Ngo, N.T.D.D.T. Lai, H.C. Le, L.T.T. Nguyen, B.T.D. Trinh, H.D. Nguyen, P.D. Pham, S. V. Dang, L.H.D. Nguyen, Chemical constituents of Aglaia elaeagnoidea and Aglaia odorata and their cytotoxicity, Nat. Prod. Res. 36 (2022) 1494–1502. https://doi.org/10.1080/14786419.2021.1893723.
J.K. Wang, Q. Guo, X.W. Zhang, L.C. Wang, Q. Liu, P.F. Tu, Y. Jiang, K.W. Zeng, Aglaia odorata Lour. extract inhibit ischemic neuronal injury potentially via suppressing p53/Puma-mediated mitochondrial apoptosis pathway, J. Ethnopharmacol. 248 (2020) 112336. https://doi.org/10.1016/j.jep.2019.112336.
M. Efdi, A. Pardede, A. Kakumu, H. Hara, Syafrizayanti, D. Arisanti, M. Ninomiya, M. Koketsu, Chemical Constituents of Aglaia odorata Leaves and Their Anti-inflammatory Effects, Nat. Prod. Commun. 12 (2017) 1717–1720.
T. Okselni, A. Santoni, A. Dharma, M. Efdi, Determination of antioxidant activity, total phenolic content, and total flavonoid content of roots, stem bark, and leaves of Elaeocarpus mastersii King, Rasayan J. Chem. 11 (2018) 1211–1216. https://doi.org/10.31788/RJC.2018.1133058.
X. Yang, Y. Yu, P. Wu, J. Liu, Y. Li, L. Tao, R. Tan, X. Hao, C. Yuan, P. Yi, Phenolic and bisamide derivatives from Aglaia odorata and their biological activities, Nat. Prod. Res. (2022) 14786419. https://doi.org/10.1080/14786419.2022.2162514.
H. Kato-Noguchi, M. Suzuki, K. Noguchi, O. Ohno, K. Suenaga, C. Laosinwattana, A Potent Phytotoxic Substance in Aglaia odorata Lour., Chem. Biodivers. 13 (2016) 549–554. https://doi.org/10.1002/cbdv.201500175.
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